The called phone is unreachable: switched off, lost its registration, or behind a NAT whose pinhole has closed.
A firewall drops SIP towards the next hop.
The next hop is overloaded or down.
What to check
Check that the called device is registered and keeps its NAT binding open (registration interval or keep-alives shorter than the router’s UDP timeout).
Trace the INVITE hop by hop to see where it stops.