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SMTP codes

SMTP 5.4.1 Recipient address rejected / no answer

Microsoft 365 “Access denied”: the recipient domain is not accepted by this server (often a misconfigured MX or Directory-Based Edge Blocking).

5.4.1
Class
5xx · Permanent failure
Retried?
No, the message bounces
Defined in
RFC 7372 / provider

What to do

How it appears in a bounce

550 5.4.1 Recipient address rejected / no answer

Paste the full bounce into the decoder — it finds every code and recipient and says what to check.

Idea?